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1

The discovery and development of antiinflammatory drugs

Kay Brune, Burkhard Hinz

Journal:

Arthritis & Rheumatism

Year:

2004

Language:

english

File:

PDF, 406 KB

english, 2004

2

Simultaneous determination of oxycodone and its major metabolite, noroxycodone, in human plasma by high-performance liquid chromatography

Olga Cheremina, Iouri Bachmakov, Antje Neubert, Kay Brune, Martin F. Fromm, Burkhard Hinz

Journal:

Biomedical Chromatography

Year:

2005

Language:

english

File:

PDF, 129 KB

english, 2005

3

Caffeine Accelerates Absorption and Enhances the Analgesic Effect of Acetaminophen

Renner, Bertold, Clarke, Geoff, Grattan, Tim, Beisel, Angelika, Mueller, Christian, Werner, Ulrike, Kobal, Gerd, Brune, Kay

Journal:

Journal of Clinical Pharmacology

Year:

2007

Language:

english

File:

PDF, 210 KB

english, 2007

4

Die Entwicklung der antipyretischen Analgetika: Weltweit umsatzstärkste Arzneimittelgruppe!

Kay Brune, Tobias Egger

Journal:

Pharmazie in unserer Zeit

Year:

2002

Language:

german

File:

PDF, 156 KB

german, 2002

5

Buffering the stomach content enhances the absorption of diflunisal in man

Bernd Nuernberg, Kay Brune

Journal:

Biopharmaceutics & Drug Disposition

Year:

1989

Language:

english

File:

PDF, 404 KB

english, 1989

6

Simultaneous determination of aceclofenac and three of its metabolites in human plasma by high-performance liquid chromatography

Burkhard Hinz, Daniel Auge, Thomas Rau, Stephan Rietbrock, Kay Brune, Ulrike Werner

Journal:

Biomedical Chromatography

Year:

2003

Language:

english

File:

PDF, 110 KB

english, 2003

7

Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers*

Lötsch, Jörn, Stockmann, Anne, Kobal, Gerd, Brune, Kay, Waibel, Rainer, Schmidt, Norbert, Geisslinger, Gerd

Journal:

Clinical Pharmacology & Therapeutics

Year:

1996

Language:

english

File:

PDF, 984 KB

english, 1996

8

COX-1 und COX-2: Funktionen und pharmakologische Beeinflussung

Dr. rer. nat. Burkhard Hinz, Prof. Dr. med. Dr. h.c. Kay Brune

Journal:

Pharmazie in unserer Zeit

Year:

1999

Language:

german

File:

PDF, 1.75 MB

german, 1999

9

The early history of non-opioid analgesics

Journal:

Year:

1997

Language:

english

File:

PDF, 1.43 MB

english, 1997

10

Opioid activity and distribution of fentanyl metabolites

Ernst Schneider, Kay Brune

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1986

Language:

english

File:

PDF, 844 KB

english, 1986

11

The Impact of Unlicensed and Off-Label Drug Use on Adverse Drug Reactions in Paediatric Patients

Dr Antje Neubert, Harald Dormann, Jutta Weiss, Tobias Egger, Manfred Criegee-Rieck, Wolfgang Rascher, Kay Brune, Burkhard Hinz

Journal:

Year:

2004

Language:

english

File:

PDF, 111 KB

english, 2004

12

Engineering of Vascularized Transplantable Bone Tissues: Induction of Axial Vascularization in an Osteoconductive Matrix Using an Arteriovenous Loop

Kneser, Ulrich, Polykandriotis, Elias, Ohnolz, Jan, Heidner, Kristina, Grabinger, Lucia, Euler, Simon, Amann, Kerstin U., Hess, Andreas, Brune, Kay, Greil, Peter, Stu¨ Rzl, Michael, Horch, Raymund E.

Journal:

Tissue Engineering

Year:

2006

Language:

english

File:

PDF, 5.86 MB

english, 2006

13

E-pharmacovigilance: development and implementation of a computable knowledge base to identify adverse drug reactions

Neubert, Antje, Dormann, Harald, Prokosch, Hans-Ulrich, Bürkle, Thomas, Rascher, Wolfgang, Sojer, Reinhold, Brune, Kay, Criegee-Rieck, Manfred

Journal:

British Journal of Clinical Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.15 MB

english, 2013

14

Advances in NSAID Development: Evolution of Diclofenac Products Using Pharmaceutical Technology

Altman, Roy, Bosch, Bill, Brune, Kay, Patrignani, Paola, Young, Clarence

Journal:

Year:

2015

Language:

english

File:

PDF, 701 KB

english, 2015

15

Nichtsteroidale Entzündungshemmer, 15. Mitt. Chirale Arylhydroxycarbonsäuren

Adriano Guarnieri, Lucilla Varoli, Silvia Burnelli, Monique Sarret, Marinella Fantuz, Kay Brune, René Lanz

Journal:

Archiv der Pharmazie

Year:

1985

File:

PDF, 343 KB

1985

16

More pronounced inhibition of cyclooxygenase 2, increase in blood pressure, and reduction of heart rate by treatment with diclofenac compared with celecoxib and rofecoxib

Burkhard Hinz, Harald Dormann, Kay Brune

Journal:

Arthritis & Rheumatism

Year:

2006

Language:

english

File:

PDF, 112 KB

english, 2006

17

Investigation of the pharmacokinetics of celecoxib by liquid chromatography–mass spectrometry

Ulrike Werner, Dierk Werner, Andreas Pahl, Ralf Mundkowski, Martin Gillich, Kay Brune

Journal:

Biomedical Chromatography

Year:

2002

Language:

english

File:

PDF, 129 KB

english, 2002

18

Simultaneous determination of leflunomide and its active metabolite, A77 1726, in human plasma by high-performance liquid chromatography

Andreas Schmidt, Bianca Schwind, Martin Gillich, Kay Brune, Burkhard Hinz

Journal:

Biomedical Chromatography

Year:

2003

Language:

english

File:

PDF, 83 KB

english, 2003

19

A liquid chromatography–mass spectrometry method for the quantiﬁcation of both etoricoxib and valdecoxib in human plasma

Ulrike Werner, Dierk Werner, Burkhard Hinz, Christoph Lambrecht, Kay Brune

Journal:

Biomedical Chromatography

Year:

2005

Language:

english

File:

PDF, 256 KB

english, 2005

20

Determination of the endocannabinoid anandamide in human plasma by high-performance liquid chromatography

Andreas Schmidt, Kay Brune, Burkhard Hinz

Journal:

Biomedical Chromatography

Year:

2006

Language:

english

File:

PDF, 125 KB

english, 2006

21

A validated high-performance liquid chromatographic assay for determination of lumiracoxib in human plasma

Olga Cheremina, Kay Brune, Burkhard Hinz

Journal:

Biomedical Chromatography

Year:

2006

Language:

english

File:

PDF, 108 KB

english, 2006

22

ChemInform Abstract: COX-1 and COX-2: Functions and Pharmacological Influence

Burkhard Hinz, Kay Brune

Journal:

Year:

1999

File:

PDF, 24 KB

1999

23

ChemInform Abstract: Development of Antipyretic Analgesics

Kay Brune, Tobias Egger

Journal:

Year:

2002

File:

PDF, 23 KB

2002

24

Pharmacokinetics of ibuprofen enantiomers in dogs

Dr. Winfried S. Beck, Gerd Geisslinger, Heidrun Engler, Kay Brune

Journal:

Year:

1991

Language:

english

File:

PDF, 527 KB

english, 1991

25

Stereoselectivity of biliary excretion of 2-arylpropionates in rats

Sabine Menzel, Winfried S. Beck, Kay Brune, Gerd Geisslinger

Journal:

Year:

1993

Language:

english

File:

PDF, 554 KB

english, 1993

26

Stereoselective pharmacokinetics of methadone in beagle dogs

Norbert Schmidt, Kay Brune, Kenneth M. Williams, Dr. Gerd Geisslinger

Journal:

Year:

1994

Language:

english

File:

PDF, 306 KB

english, 1994

27

In vivo magnetic resonance imaging of dendritic cell migration into the draining lymph nodes of mice

Dirk Baumjohann, Andreas Hess, Lubos Budinsky, Kay Brune, Gerold Schuler, Manfred B. Lutz

Journal:

European Journal of Immunology

Year:

2006

Language:

english

File:

PDF, 588 KB

english, 2006

28

Variability of inversion of (R)-flurbiprofen in different species

Sabine Menzel-Soglowek, Gerd Geisslinger, Winfried S. Beck, Kay Brune

Journal:

Journal of Pharmaceutical Sciences

Year:

1992

Language:

english

File:

PDF, 371 KB

english, 1992

29

Novel 5-aminosalicylic acid NSAID conjugates: synthesis; pharmacological and toxicological properties

Norbert L. Mo¨ller, Klaus E. Dietzel, H. Thomas Schneider, Kay Brune

Journal:

European Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 612 KB

english, 1989

30

Imaging of hyperalgesia in rats by functional MRI

Andreas Hess, Marina Sergejeva, Lubos Budinsky, Hanns Ulrich Zeilhofer, Kay Brune

Journal:

European Journal of Pain

Year:

2007

Language:

english

File:

PDF, 385 KB

english, 2007

31

Cerebrospinal fluid prostaglandins after systemic dipyrone intake*

Levy, Micha, Brune, Kay, Zylber-Katz, Ester, Cohen, Oren, Caraco, Yoseph, Geisslinger, Gerd

Journal:

Clinical Pharmacology & Therapeutics

Year:

1998

Language:

english

File:

PDF, 604 KB

english, 1998

32

High-performance liquid chromatographic determination of pentazocine in plasma

Norbert Moeller, Klaus Dietzel, Bernd Nuernberg, Gerd Geisslinger, Kay Brune

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1990

Language:

english

File:

PDF, 343 KB

english, 1990

33

Selective and rapid liquid chromatography–mass spectrometry method for the quantification of rofecoxib in pharmacokinetic studies with humans

Ulrike Werner, Dierk Werner, Ralf Mundkowski, Martin Gillich, Kay Brune

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

2001

Language:

english

File:

PDF, 734 KB

english, 2001

34

Computerized surveillance of adverse drug reactions in hospital: pilot study

Tatyana Azaz-Livshits, Micha Levy, Batami Sadan, Meir Shalit, Gerd Geisslinger, Kay Brune

Journal:

British Journal of Clinical Pharmacology

Year:

1998

Language:

english

File:

PDF, 78 KB

english, 1998

35

Prolyl isomerases in a minimal cell : Catalysis of protein folding by trigger factor from Mycoplasma genitalium

Holger Bang, Anja Pecht, Guenter Raddatz, Tom Scior, Werner Solbach, Kay Brune, Andreas Pahl

Journal:

Year:

2000

Language:

english

File:

PDF, 1.05 MB

english, 2000

36

Normal sensitivity to acute pain, but increased inflammatory hyperalgesia in mice lacking the nociceptin precursor polypeptide or the nociceptin receptor

Ulrike B. Depner, Rainer K. Reinscheid, Hiroshi Takeshima, Kay Brune, Hanns Ulrich Zeilhofer

Journal:

European Journal of Neuroscience

Year:

2003

Language:

english

File:

PDF, 251 KB

english, 2003

37

Inhibition of Noxious Stimulus-Induced Spinal Prostaglandin E2 Release by Flurbiprofen Enantiomers : A Microdialysis Study

Gerd Geisslinger, Uta Muth-Selbach, Ovidiu Coste, Gregor Vetter, Andreas Schrödter, Hans-Georg Schaible, Kay Brune, Irmgard Tegeder

Journal:

Journal of Neurochemistry

Year:

2000

Language:

english

File:

PDF, 137 KB

english, 2000

38

Classical absorption theory and the development of gastric mucosal damage associated with the non-steroidal anti-inflammatory drugs

Keith McCormack, Kay Brune

Journal:

Archives of Toxicology

Year:

1987

Language:

english

File:

PDF, 921 KB

english, 1987

39

Hühnergranulozyten: Ein Modell für die antimikrobielle Funktion peroxidasefreier menschlicher Granulozyten

Journal:

Annals of Hematology

Year:

1973

File:

PDF, 2.81 MB

1973

40

How aspirin might work: A pharmacokinetic approach

Journal:

Inflammation Research

Year:

1974

Language:

english

File:

PDF, 228 KB

english, 1974

41

The avian microcrystal arthritis II. Central versus peripheral effects of sodium salicylate, acetaminophen and colchicine

Kay Brune, Käthy Bucher, Dieter Walz

Journal:

Inflammation Research

Year:

1974

Language:

english

File:

PDF, 581 KB

english, 1974

42

The avian microcrystal arthritis III. invasion and enzyme-release from leukocytes at the site of inflammation

Kay Brune, Markus Glatt

Journal:

Inflammation Research

Year:

1974

Language:

english

File:

PDF, 526 KB

english, 1974

43

The avian microcrystal arthritis IV. The impact of sodium salicylate, acetaminophen and colchicine on leukocyte invasion and enzyme liberation in vivo

Kay Brune, Markus Glatt

Journal:

Inflammation Research

Year:

1974

Language:

english

File:

PDF, 557 KB

english, 1974

44

Workshop session summary: Prostaglandins: immunoregulatorsin vivo?

Journal:

Inflammation Research

Year:

1984

Language:

english

File:

PDF, 98 KB

english, 1984

45

Non-acidic pyrazoles: Inhibition of prostaglandin production, carrageenan oedema and yeast fever

Kay Brune, Hans Alpermann

Journal:

Inflammation Research

Year:

1983

Language:

english

File:

PDF, 316 KB

english, 1983

46

The amphiprotic character of azapropazone and its relevance to the gastric mucosa

Keith McCormack, Kay Brune

Journal:

Archives of Toxicology

Year:

1990

Language:

english

File:

PDF, 542 KB

english, 1990

47

Pharmacological control of leukotriene and prostaglandin production from mouse peritoneal macrophages

Kay Brune, Ute Aehringhaus, Bernhard A. Peskar

Journal:

Inflammation Research

Year:

1984

Language:

english

File:

PDF, 598 KB

english, 1984

48

How aspirin might work: A pharmacokinetic approach

Journal:

Inflammation Research

Year:

1994

Language:

english

File:

PDF, 320 KB

english, 1994

49

The avian microcrystal arthritis II. Central versus peripheral effects of sodium salicylate, acetaminophen and colchicine

Kay Brune, Käthy Bucher, Dieter Walz

Journal:

Inflammation Research

Year:

1994

Language:

english

File:

PDF, 614 KB

english, 1994

50

Colchicine in avian sodium urate and calcium pyrophosphate microcrystal arthritis

George L. Floersheim, Kay Brune, Karl Seiler

Journal:

Inflammation Research

Year:

1973

Language:

english

File:

PDF, 280 KB

english, 1973

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